PROGESTERONE - Uses, Side Effects, and More

Estrogens interacts with PROGESTERONE

Progesterone and estrogen are both hormones. They are often taken together. Progesterone can decrease some of the side effects of estrogen. But progesterone might also decrease the beneficial effects of estrogen. Taking progesterone along with estrogen might cause breast tenderness. Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.

Paclitaxel (Abraxane, Onxol) interacts with PROGESTERONE

Injecting high-doses of progesterone intravenously (by IV) in combination with the drug paclitaxel might increase levels of paclitaxel in the blood. However, the combination does not seem to increase the side effects of paclitaxel. Until more is known, use progesterone cautiously or avoid using in patients being treated with paclitaxel.

• For hormone replacement therapy (HRT): 200 mg micronized progesterone (Prometrium) per day is typically taken for 12 days of a 25-day cycle with 0.625 mg conjugated estrogens.
• For inability to become pregnant within a year of trying to conceive (infertility): 300 mg micronized progesterone per day is usually taken for about 30 days after the embryo has been placed in the uterus.
• For preventing preterm birth: 100 mg micronized progesterone twice daily starting at week 20 of pregnancy has been used.

• For breast pain (mastalgia): a typical dose of 4 grams of vaginal cream containing 2.5% natural progesterone is placed inside the vagina from the 19th to the 25th day of a 28-day cycle.
• For absence of menstrual periods (amenorrhea): one applicator (90 mg) of progesterone gel (Crinone 4% or 8%) is typically placed inside the vagina every other day for 6 days per month.
• For reducing abnormal thickening of the lining of the uterus (endometrial hyperplasia): a dose of 90 mg (Crinone 8%) or 100 mg progesterone cream placed inside the vagina daily from day 10 to day 25 or on days 17, 19, 21, 23, 25, and 27 of a 28-day cycle has been used.
• For inability to become pregnant within a year of trying to conceive (infertility): 90 mg progesterone (Crinone 8%) or 100-600 mg of other types of progesterone have been placed inside the vagina every day for about 2 weeks after the embryo has been placed in the uterus.
• For preventing premature labor: 90-400 mg progesterone in the form of gel or an insert has been placed in the vagina every day starting at about 18-22 weeks of pregnancy.

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