What is Lymphoma?

Articles On Leukemia & Lymphoma

Lymphoma is cancer that begins in infection-fighting cells of the immune system, called lymphocytes. These cells are in the lymph nodes, spleen, thymus, bone marrow, and other parts of the body. When you have lymphoma, lymphocytes change and grow out of control.

There are two main types of lymphoma:

Non-
Hodgkin

Non-Hodgkin and Hodgkin lymphoma involve different types of lymphocyte cells. Every type of lymphoma grows at a different rate and responds differently to treatment.

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Lymphoma is very treatable, and the outlook can vary depending on the type of lymphoma and its stage. Your doctor can help you find the right treatment for your type and stage of the illness.

Lymphoma is different from leukemia. Each of these cancers starts in a different type of cell.

Lymphoma starts in infection-fighting lymphocytes.
Leukemia starts in blood- forming cells inside bone marrow.

Lymphoma is also not the same as lymphedema, which is a collection of fluid that forms in body tissues when there is damage or blockage to the lymph system.

Causes

Scientists don't know what causes lymphoma in most cases.

You might be more at risk if you:

Are in your 60s or older for non-Hodgkin lymphoma
Are between 15 and 40 or older than 55 for Hodgkin lymphoma
Are male, although certain subtypes may be more common in females
Have a weak immune system from HIV/AIDS, an organ transplant, or because you were born with an immune disease
Have an immune system disease such as rheumatoid arthritis, Sjögren's syndrome, lupus, or celiac disease
Have a close relative who had lymphoma
Were exposed to benzene or chemicals that kill bugs and weeds
Were treated for cancer with radiation

Symptoms

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Warning signs of lymphoma include:

Swollen glands (lymph nodes), often in the neck, armpit, or groin that are painless
Cough
Shortness of breath
Fever
Night sweats
Fatigue
Weight loss
Itching

Many of these symptoms can also be warning signs of other illnesses. See your doctor to find out for sure if you have lymphoma.

Getting a Diagnosis

Before you have any tests, your doctor will want to know:

How have you been feeling?
When did you first notice changes?
Do you have pain? Where?
How is your appetite?
Have you lost any weight?
Do you feel tired or weak?
What are your current medical problems and treatments?
What is your past medical history including conditions and treatments?
What is your family medical history?

Your doctor will do a physical exam, including a check for swollen lymph nodes. This symptom doesn't mean you have cancer. Most of the time, an infection -- unrelated to cancer -- causes swollen lymph nodes.

You might get a lymph node biopsy to check for cancer cells. For this test, a doctor will remove all or part of a lymph node, or use a needle to take a small amount of tissue from the affected node.

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You might also have one of these tests to help diagnose, stage, or manage lymphoma:

Bone marrow aspiration or biopsy. Your doctor uses a needle to remove fluid or tissue from your bone marrow -- the spongy part inside bone where blood cells are made -- to look for lymphoma cells.
Chest X-ray. It will be done using low doses of radiation radiation to make images of the inside of your chest.
MRI. A technician will use powerful magnets and radio waves to make pictures of organs and structures inside your body.
PET scan. This imaging test uses a radioactive substance to look for cancer cells in your body.
Molecular test. This test is used to find changes to genes, proteins, and other substances in cancer cells to help your doctor figure out which type of lymphoma you have.
Blood tests. These check the number of certain cells, levels of other substances, or evidence of infection in your blood.

Treatment

The treatment you get depends on what type of lymphoma you have and its stage.

The main treatments for non-Hodgkin lymphoma are:

Chemotherapy, which uses drugs to kill cancer cells
Radiation therapy, which uses high-energy rays to destroy cancer cells
Immunotherapy, which uses your body's immune system to attack cancer cells
Targeted therapy that targets aspects of lymphoma cells to curb their growth

The main treatments for Hodgkin lymphoma are:

Chemotherapy
Radiation therapy
Immunotherapy

If these treatments don't work, you might have a stem cell transplant. First you'll get very high doses of chemotherapy. This treatment kills cancer cells, but it also destroys stem cells in your bone marrow that make new blood cells. After chemotherapy, you will get a transplant of stem cells to replace the ones that were destroyed.

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Two types of stem cell transplants can be done:

An autologous transplant uses your own stem cells.
An allogeneic transplant uses stem cells taken from a donor.

Taking Care of Yourself

Lymphoma treatment can cause side effects. Talk to your medical team about ways to relieve any symptoms you have.

Also ask your doctor about changes to your diet and exercise that can help you feel better during your treatment. Ask a dietitian for help if you're not sure what types of food to eat. Exercises like walking or swimming can relieve fatigue and help you feel better during treatments like chemotherapy and radiation. You might also try alternative therapies like relaxation, biofeedback, or guided imagery to help relieve pain.

What to Expect

Treatments have improved a lot, and many people do very well after treatment. Your doctor will talk to you about a survivorship care plan. Your outlook depends on:

The kind of lymphoma you have
How far the cancer has spread
Your age
The type of treatment you get
What other health problems you have

Getting Support (Resources)

You can get support from people who have gone through this kind of illness.

Contact the Leukemia & Lymphoma Society or Lymphoma Research Foundation to learn more.

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