DANSHEN - Uses, Side Effects, and More

Digoxin (Lanoxin) interacts with DANSHEN

Digoxin (Lanoxin) helps the heart beat more strongly. Danshen also seems to affect the heart. Taking danshen along with digoxin can increase the effects of digoxin and increase the risk of side effects. Do not take danshen if you are taking digoxin (Lanoxin) without talking to your healthcare professional.

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with DANSHEN

Danshen might slow blood clotting. Taking danshen along with medications that also slow clotting might increase the chances of bruising and bleeding. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Warfarin (Coumadin) interacts with DANSHEN

Warfarin is used to slow blood clotting. Danshen might increase how long warfarin stays in the body and increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of warfarin might need to be changed.

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with DANSHEN

Some medications are changed and broken down by the liver. Danshen use might increase how quickly the body breaks down some medications. Taking danshen along with some medications that are broken down by the liver might decrease the effectiveness of some of these medications. Before taking danshen talk to your healthcare provider if you are taking any medications that are changed by the body. Some medications changed by the liver include lovastatin (Mevacor), clarithromycin (Biaxin), cyclosporine (Neoral, Sandimmune), diltiazem (Cardizem), estrogens, indinavir (Crixivan), triazolam (Halcion), and others.

Midazolam (Versed) interacts with DANSHEN

Midazolam (Versed) is changed and broken down by the body. Danshen might increase how quickly midazolam (Versed) is broken down by the body. This might decrease the effects of midazolam (Versed).

Aspirin interacts with DANSHEN

Taking danshen along with aspirin might increase how much aspirin is in the blood. This might increase the effects and side effects of aspirin.

Clopidogrel (Plavix) interacts with DANSHEN

Clopidogrel (Plavix) is changed and broken down by the liver. Danshen might decrease how quickly clopidogrel (Plavix) is changed and broken down by the liver. This might increase the effects and side effects of clopidogrel (Plavix).

Fexofenadine (Allegra) interacts with DANSHEN

Fexofenadine (Allegra) is moved by pumps in cells. Danshen might make these pumps less active and increase the amount of fexofenadine (Allegra) that gets absorbed by the body. This might increase the amount of fexofenadine (Allegra) in the body, which could lead to more side effects.

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with DANSHEN

Some medications are changed and broken down by the liver. Danshen might decrease how quickly the liver breaks down some medications. Taking danshen along with some medications that are changed by the liver might increase the effects and side effects of these medications. Before taking danshen, talk to your healthcare provider if you take any medications that are changed by the liver. Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), zileuton (Zyflo), zolmitriptan (Zomig), and others.

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with DANSHEN

Some medications are changed and broken down by the liver. Danshen might decrease how quickly the liver breaks down some medications. Taking danshen along with some medications that are changed by the liver might increase the effects and side effects of some of these medications. Before taking danshen, talk to your healthcare provider if you take any medications that are changed by the liver. Some of these medications that are changed by the liver include nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), piroxicam (Feldene), and celecoxib (Celebrex); amitriptyline (Elavil); warfarin (Coumadin); glipizide (Glucotrol); losartan (Cozaar); and others. Use danshen cautiously or avoid in patients taking these drugs.

Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates) interacts with DANSHEN

Some medications are changed and broken down by the liver. Danshen might decrease how quickly the liver breaks down some medications. Taking danshen along with some medications that are changed by the liver might increase the effects and side effects of some of these medications. Before taking danshen, talk to your healthcare provider if you take any medications that are changed by the liver. Some medications that are changed by the liver include acetaminophen, chlorzoxazone (Parafon Forte), ethanol, theophylline, and anesthetics such as enflurane (Ethrane), halothane (Fluothane), isoflurane (Forane), and methoxyflurane (Penthrane).

Medications moved by pumps in cells (P-Glycoprotein substrates) interacts with DANSHEN

Some medications are moved by pumps in cells. Danshen might make these pumps less active and increase the amount of some medications that get absorbed by the body. This might increase the amount of some medications in the body, which could lead to more side effects. Some medications that are moved by these pumps include some chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), protease inhibitors (amprenavir, indinavir, nelfinavir, saquinavir), H2 antagonists (cimetidine, ranitidine), some calcium channel blockers (diltiazem, verapamil), corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.

Rosuvastatin (Crestor) interacts with DANSHEN

Danshen might increase levels of rosuvastatin (Crestor) in the blood. This might increase the effects and side effects of rosuvastatin (Crestor).

Amlodipine (Norvasc) interacts with DANSHEN

Taking danshen along with amlodipine might decrease how much amlodipine is in the blood. This might decrease the effects of amlodipine.

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