HESPERIDIN - Uses, Side Effects, and More

Celiprolol (Celicard) interacts with HESPERIDIN

Hesperidin may reduce how much celiprolol the body absorbs. This might decrease how well celiprolol works. Do not take hesperidin with celiprolol.

Diltiazem (Cardizem, others) interacts with HESPERIDIN

Hesperidin may reduce how much diltiazem the body absorbs. This might decrease how well diltiazem works. Do not take diltiazem with hesperidin.

Medications for high blood pressure (Antihypertensive drugs) interacts with HESPERIDIN

Hesperidin might decrease blood pressure. Taking hesperidin along with medications used to lower high blood pressure might cause your blood pressure to go too low. Some medications for high blood pressure include nifedipine (Adalat, Procardia), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem), isradipine (DynaCirc), felodipine (Plendil), amlodipine (Norvasc), and others.

Medications moved by pumps in cells (P-Glycoprotein Substrates) interacts with HESPERIDIN

Some medications are moved by pumps in cells. Hesperidin might make these pumps less active and increase the amount of some medications that get absorbed by the body. This might increase the amount of some medications in the body, which could lead to more side effects. But there is not enough information to know if this is a big concern. Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with HESPERIDIN

Hesperidin might slow blood clotting. Taking hesperidin along with medications that also slow blood clotting might increase the risk of bruising and bleeding and others.

Sedative medications (CNS depressants) interacts with HESPERIDIN

Hesperidin might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking hesperidin along with sedative medications might cause too much sleepiness. Taking hesperidin along with sedative medications used in surgery might cause prolonged sedation. Some sedative medications include pentobarbital (Nembutal), phenobarbital (Luminal), secobarbital (Seconal), thiopental (Pentothal), fentanyl (Duragesic, Sublimaze), morphine, propofol (Diprivan), and others.

Verapamil (Calan, others) interacts with HESPERIDIN

Hesperidin may increase how much verapamil the body absorbs. This might increase the effects and side effects of verapamil. Do not take verapamil with hesperidin.

• For poor circulation that can cause the legs to swell (chronic venous insufficiency or CVI): A specific combination product containing hesperidin methyl chalcone 150 mg, butcher's broom root extract 150 mg, and ascorbic acid 100 mg has been used. Also, a combination of 100-150 mg of hesperidin with 900-1350 mg of diosmin taken daily for 2-6 months has been used.
• For hemorrhoids: A combination of 150 mg of hesperidin plus 1350 mg of diosmin twice daily for 4 days, followed by 100 mg of hesperidin and 900 mg of diosmin twice daily for 3 days has been used. Also, a combination of 50 mg of hesperidin plus 450 mg of diosmin twice daily for 3 months has been used to prevent the return of hemorrhoids.
• For sores caused by weak blood circulation (venous leg ulcer): A combination of 100 mg of hesperidin and 900 mg of diosmin daily for up to 2 months has been used.

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