DIOSMIN - Uses, Side Effects, and More

Chlorzoxazone (Parafon Forte, Paraflex) interacts with DIOSMIN

The body breaks down chlorzoxazone (Parafon Forte, Paraflex) to get rid of it. Diosmin might decrease how quickly the body breaks down chlorzoxazone (Parafon Forte, Paraflex). Taking diosmin along with chlorzoxazone (Parafon Forte, Paraflex) might increase the effects and side effects of chlorzoxazone (Parafon Forte, Paraflex).

Diclofenac (Voltaren, others) interacts with DIOSMIN

The body breaks down diclofenac (Voltaren, others) to get rid of it. Diosmin might decrease how quickly the body breaks down diclofenac (Voltaren, others). Taking diosmin along with diclofenac (Voltaren, others) might increase the effects and side effects of diclofenac (Voltaren, others).

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with DIOSMIN

Some medications are changed and broken down by the liver. Diosmin might decrease how quickly the liver breaks down some medications. Taking diosmin along with some medications that are broken down by the liver might increase the effects and side effects of these medications. Before taking diosmin, talk to your healthcare provider if you take any medications that are changed by the liver. Some medications that are changed by the liver include celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), warfarin (Coumadin), and others.

Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates) interacts with DIOSMIN

Some medications are changed and broken down by the liver. Diosmin might decrease how quickly the liver breaks down some medications. Taking diosmin along with some medications that are broken down by the liver may increase the effects and side effects of these medications. Some medications changed by the liver include acetaminophen, chlorzoxazone (Parafon Forte), ethanol, theophylline, and anesthetics such as enflurane (Ethrane), halothane (Fluothane), isoflurane (Forane), and methoxyflurane (Penthrane).

Medications moved by pumps in cells (P-Glycoprotein Substrates) interacts with DIOSMIN

Some medications are moved by pumps in cells. Diosmin might make these pumps less active and increase the amount of some medications that get absorbed by the body. This might increase the amount of some medications in the body, which could lead to more side effects. Some medications that are moved by these pumps include some chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), protease inhibitors (amprenavir, indinavir, nelfinavir, saquinavir), H2 antagonists (cimetidine, ranitidine), some calcium channel blockers (diltiazem, verapamil), corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with DIOSMIN

Diosmin might slow blood clotting. Taking diosmin along with medications that also slow blood clotting might increase the chances of bruising and bleeding. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Carbamazepine (Tegretol) interacts with DIOSMIN

The body breaks down carbamazepine (Tegretol) to get rid of it. Diosmin might decrease how quickly the body breaks down carbamazepine (Tegretol). Taking diosmin along with carbamazepine (Tegretol) might increase the effects and side effects of carbamazepine (Tegretol).

Fexofenadine (Allegra) interacts with DIOSMIN

Some medications including fexofenadine (Allegra) are moved by pumps in cells. Diosmin might make these pumps less active and increase how much of some medications get absorbed by the body. This might cause more side effects from some medications.

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with DIOSMIN

Some medications are changed and broken down by the liver. Diosmin may decrease how quickly the liver breaks down some medications. Taking diosmin along with some medications may increase the effects and side effects of these medications. Before taking diosmin, talk to your health care provider if you are taking any medications that are changed by the liver. Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), clarithromycin (Biaxin), erythromycin, cyclosporine (Neoral, Sandimmune), amlodipine (Norvasc), verapamil (Calan, Isoptin), diltiazem (Cardizem), estrogens, indinavir (Crixivan), fexofenadine (Allegra), triazolam (Halcion), alprazolam (Xanax), and many others.

• For hemorrhoids: For treating hemorrhoids, 1350 mg of diosmin plus 150 mg of hesperidin twice daily for 4 days followed by 900 mg of diosmin and 100 mg of hesperidin twice daily for 3 days has been used. Also, 300 mg of diosmin, 300 mg of troxerutin, and 300 mg of hesperidin three times daily for 3 days, followed by two times daily for 2 days, and then once daily for 7 days has been used. Thereafter, 300 mg of diosmin, 300 mg of troxerutin, and 100 mg of hesperidin has been used daily for one month. Some researchers also try 600 mg of diosmin three times daily for 4 days, followed by 300 mg twice daily for 10 days, in combination with 11 grams of psyllium daily. However, this lower diosmin dose does not seem to be as effective.
• For leg ulcers caused by poor circulation (venous stasis ulcers): 900 mg of diosmin plus 100 mg of hesperidin daily has been used for up to 2 months.

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